【海洋环保】曹美文

发布者:李庆喆发布时间:2022-12-06浏览次数:16

 

一、个人概况

曹美文,副教授,物理化学博士,博士生导师。研究领域为应用胶体与界面化学,包括新型两亲分子自组装及其生物应用、特种油料研发及海上溢油处理应用等。先后承担各类纵向及横向科研课题20余项,其中主持国家自然科学基金面上及青年基金项目4项,主持省部级项目3项及横向课题12项。2020年获省部级科技进步奖一等奖一项。先后在Coordin Chem Rev、Chem Eng J、ACS Appl Mater Interfaces等国际一流期刊发表SCI论文90余篇(其中第一作者及通讯作者论文45篇;高被引论文4篇;SCI一区论文16篇)。致力于新技术、新工艺的研发和转化,第一发明人申请国家发明专利30余项,已授权15项,实现专利转化2项。担任国际一流学术刊物Front. Bioeng. Biotechnol.(SCI二区)副主编及Nanomaterials(SCI二区)的客座编辑。获2021年“青岛西海岸新区优秀年人才”称号。

 

二、研究方向

1.纳米生物功能材料及药物载体的制备及应用

2.特种油料研发及其海上溢油处理应用

3.新型智能凝胶材料的制备及污染物防除应用

 

三、合作领域

1.特种油料研发及应用

2.海上溢油污染处理

 

四、承担项目

(一)纵向课题

1.基于多肽组装构筑Cas9-sgRNA核糖核蛋白递送载体,国家自然科学基金面上项目,2022.01.01—2025.12.31,主持人;

2.基于多肽/DNA超分子组装构筑的人工病毒,国家自然科学基金面上项目,2019.01.01—2022.12.31,主持人;

3.两亲性短肽的细胞内自组装研究,国家自然科学基金面上项目, 2015.01.01—2018.12.31,主持人;

4.肽核酸(PNA)基两亲分子的设计、合成及性质研究,国家自然科学基金青年科学基金项目,2011.01.01—2013.12.31,主持人;

5.完全氨基酸构成的Gemini两亲分子的设计、合成及自组装,山东省自然科学基金青年基金项目,2010.01.01—2012.12.31,主持人;

6.Gemini型肽基双亲分子的设计、合成及自组装行为研究,教育部高校博士学科点专项科研基金,2010.01.01—2012.12.31,主持人;

7.生物响应性药物载体的构筑及应用,自主创新科研计划项目(教育部高校专项建设经费),2017.01.01—2019.12.31,主持人;

8.双子型多肽表面活性剂的设计合成及自组装,自主创新科研计划项目(教育部高校专项建设经费),2009.12.01—2011.12.31,主持人。

(二)横向课题

1.KPS与甜菜碱复配体系乳化增溶原油能力表征等,中国石油天然气有限公司勘探开发研究院,2020.06.01—2021.05.31,主持人.

2.纳米材料制备与表征,中国石油天然气有限公司勘探开发研究院,2021.12.06—2022.06.30,主持人;

3.日化用品的配方优化及分析,宝洁中国(北京),2021.04.01—2023.05.31,主持人。

4.口腔护理和洗护用品的配方优化及分析,宝洁中国(北京),2020.05.01—2022.06.30,主持人。

5.喷火油料化学组成、聚集形态、非牛顿流体特性测试,中国军事科学院防化研究院,2021.05.01—2023.06.30,主持人。

6.多孔材料结构和表面化学分析,中国原子能科学研究院, 2021.12.01—2023.11.30,主持人。

7.耐温抗钙镁聚合物结构及溶液中zeta电位测试,中石化胜利油田石油勘探院,2021.06.01—2021.12.31,主持人;

8.普通稠油油藏驱油用聚合物溶液结构测试,中石化胜利油田石油勘探院,2015.12.17—2016.04.30,主持人。

 

五、代表性成果

1.论文发表

1)Zhang, Q.; Liu, Y.; Xie, T.; Shang-guan, Y.; Tian, M.; Zhang, Q.; Cao, M.*: Sulfate ion-triggered self-assembly transitions of amphiphilic short peptides by force balance adjustment. Colloids and Surfaces A: Physicochemical and Engineering Aspects 2022, 637, 128252.

2)Xu, X.; Liu, Y.; Yang, Y.; Wu, J.; Cao, M.*; Sun, L.*: One-pot synthesis of functional peptide-modified gold nanoparticles for gene delivery. Colloids and Surfaces A: Physicochemical and Engineering Aspects 2022, 640, 128491.

3)Sun, S.; Zhang, Z.; Xiang, Y.; Cao, M.*; Yu, D.*: Amino Acid-Mediated Synthesis of the ZIF-8 Nanozyme That Reproduces Both the Zinc-Coordinated Active Center and Hydrophobic Pocket of Natural Carbonic Anhydrase. Langmuir 2022, 38 (4), 1621-1630.

4)Cao, M.*; Zhuang, Z.; Liu, Y.; Zhang, Z.; Xuan, J.; Zhang, Q.; Wang, W.,Peptide-mediated green synthesis of the MnO2@ZIF-8 core–shell nanoparticles for efficient removal of pollutant dyes from wastewater via a synergistic process. Journal of Colloid and Interface Science 2022, 608 (3), 2779-2790.

5)Cao, M.*; Zhang, Z.; Zhang, X.; Wang, Y.; Wu, J.; Liu, Z.; Sun, L.*; Wang, D.; Yue, T.*; Han, Y.; Wang, Y.; Wang, Y.; Wang, M.*: Peptide Self-assembly into Stable Capsid-Like Nanospheres and Co-assembly with DNA to Produce Smart Artificial Viruses. Journal of Colloid and Interface Science 2022.

6)曹美文*,王栋,纳米复合抗菌水凝胶的制备与性能.实验技术与管理 2021, 38 (12), 180-183.

7)Tian, M.; Chen, X.; Zhang, Q.; Zou, X.; Ma, D.; Xuan, J.; Wang, W.; Cao, M.*: Peptide-Mediated Synthesis of Zeolitic Imidazolate Framework-8: Effect of Molecular Hydrophobicity, Charge Number and Charge Location. Nanomaterials 2021, 11 (10), 2665.

8)Nie, Y.; Tian, M.; Zhang, Q.; Wang, L.; Ji, Z.; Chen, X.; Yang, S.; Song, W.; Wu, C.; Xu, H.; Cao, M.*: Controlled fabrication of biocompatible graphene oxide Langmuir–Blodgett films by size and surface property manipulation. Journal of Dispersion Science and Technology 2021, 1-12.

9)Nie, Y.; Ma, S.; Tian, M.; Zhang, Q.; Huang, J.; Cao, M.*; Li, Y.; Sun, L.; Pan, J.; Wang, Y.; Bi, P.*; Xu, H.; Zeng, J.*; Wang, S.; Xia, Y.: Superhydrophobic silane-based surface coatings on metal surface with nanoparticles hybridization to enhance anticorrosion efficiency, wearing resistance and antimicrobial ability. Surface and Coatings Technology 2021, 410, 126966.

10)Li, Y.; Ma, S.; Fang, X.; Wu, C.; Chen, H.; Zhang, W.; Cao, M.*; Liu, J.*: Water Hardness Effect on the Association and Adsorption of Cationic Cellulose Derivative/Anionic Surfactant Mixtures for Fabric Softener Application. Colloids and Surfaces A: Physicochemical and Engineering Aspects 2021, 626, 127031.

11)Li, J.; Li, Z.; Cao, M.*; Liu, J.*: Expression and characterization of catechol 1,2-dioxygenase from Oceanimonas marisflavi 102-Na3. Protein Expr Purif 2021, 188, 105964.

12)Cao, M.*; Shen, Y.; Yan, Z.; Wei, Q.; Jiao, T.; Shen, Y.; Han, Y.; Wang, Y.; Wang, S.; Xia, Y.; Yue, T.*: Extraction-like removal of organic dyes from polluted water by the graphene oxide/PNIPAM composite system. Chemical Engineering Journal 2021, 405, 126647.

13)Xuan, J.; Liu, Y.; Xu, X.; Ding, Z.; Zhuang, Z.; Zhang, Y.; Yan, Y.; Cao, M.*; Wang, S.; Xia, Y.; Sun, L.*: Peptide-Mediated Synthesis of Zeolitic Imidazolate Framework-8 with Controllable Morphology and Size. Langmuir 2020, 36 (46), 13981-13988.

14)Xiu, Y.; Xu, L.; Zhang, X.; Wang, X.; Liu, F.; Xia, Y.; Cao, M.*; Wang, S.*: Mechanistic Process Understanding of the Biomimetic Construction of Porphyrin-Based Light-Capturing Antennas from Self-Assembled Fmoc-Blocked Peptide Templates. ACS Sustainable Chemistry & Engineering 2020, 8 (41), 15761-15771.

15)Wang, Y.; Xuan, J.; Zhao, W.; Ding, Z.; Zhang, L.; Du, R.; Zhang, A.; Wang, Y.; Li, D.; Cao, M.*: Smart and selective cancer-killing peptides with cell penetrating sequence and dual-targeting mechanism. Colloids and Surfaces A: Physicochemical and Engineering Aspects 2020, 586, 124185.

16)Wang, Y.; Nie, Y.; Ding, Z.; Yao, M.; Du, R.; Zhang, L.; Wang, S.; Li, D.; Wang, Y.; Cao, M.*: An Amphiphilic Peptide with Cell Penetrating Sequence for Highly Efficient Gene Transfection. Colloids and Surfaces A: Physicochemical and Engineering Aspects 2020, 590, 124529.

17)Xu, X.; Liu, Y.; Fu, W.; Yao, M.; Ding, Z.; Xuan, J.; Li, D.; Wang, S.; Xia, Y.; Cao, M.*: Poly(N-isopropylacrylamide)-Based Thermoresponsive Composite Hydrogels for Biomedical Applications. Polymers 2020, 12, 580. (SCI二区,IF:3.4266.182)

18)Nie, Y.; Huang, J.; Ma, S.; Li, Z.; Shi, Y.; Yang, X.; Fang, X.; Zeng, J.; Bi, P.*; Qi, J.; Wang, S.; Xia, Y.; Jiao, T.*; Li, D.; Cao, M.*: Aplplied Surface Science 2020, 527, 146915.(SCI二区,IF:6.182)

19)Meng, Y.; Yin, J.; Jiao, T.*; Bai, J.; Zhang, L.; Su, J.; Liu, S.; Bai, Z.; Cao, M.*; Peng, Q.*: Self-assembled copper/cobalt-containing polypyrrole hydrogels for highly efficient ORR electrocatalysts. Journal of Molecular Liquids 2020, 298, 112010.(SCI二区,IF:5.065)

20)Wang, Y.; Xuan, J.; Zhao, W.; Ding, Z.; Zhang, L.; Du, R.; Zhang, A.; Wang, Y.; Li, D.; Cao, M.*: Smart and selective cancer-killing peptides with cell penetrating sequence and dual-targeting mechanism. Colloids and Surfaces A: Physicochemical and Engineering Aspects 2020, 586, 124185. (SCI三区,IF:3.99)

21)Wang, Y.; Nie, Y.; Ding, Z.; Yao, M.; Du, R.; Zhang, L.; Wang, S.; Li, D.; Wang, Y.; Cao, M.*: An Amphiphilic Peptide with Cell Penetrating Sequence for Highly Efficient Gene Transfection. Colloids and Surfaces A: Physicochemical and Engineering Aspects 2020, 590, 124529.(SCI三区,IF:3.99,封面文章)

22)Cao, M.*; Wang, Y.; Hu, X.; Gong, H.; Li, R.; Cox, H.; Zhang, Jing.; Waigh, T. A.; Xu, H.; Lu, J. R.: Reversible Thermoresponsive Peptide-PNIPAM Hydrogels for Controlled Drug Delivery. Biomacromolecules 2019, DOI: 10.1021/acs.biomac.9b01009.(SCI二区,IF:5.667)

23)Cao, M.*; Xing, R.; Chang, R.; Wang, Y.; Yan, X.*: Peptide-coordination self-assembly for the precise design of theranostic nanodrugs. Coordination Chemistry Reviews 2019, 397, 14-27.(SCI一区,IF:13.476)

24)Cao, M.*; Lu, S.; Wang, N.; Xu, H.*; Cox, H.; Li, R.; Waigh, T.; Han, Y.; Wang, Y.; Lu, J. R.*: Enzyme-Triggered Morphological Transition of Peptide Nanostructures for Tumor-Targeted Drug Delivery and Enhanced Cancer Therapy. Applied Materials & Interfaces 2019, 11, 16357-16366. (SCI一区,IF:8.456)

25)Cao, M.*; Shen, Y.; Wang, Y.; Wang, X.; Li, D.: Self-Assembly of Short Elastin-like Amphiphilic Peptides: Effects of Temperature, Molecular Hydrophobicity and Charge Distribution. Molecules 2019, 24, 202.(SCI三区,IF:3.06)

26)Cao, M.*; Wang, Y.; Zhao, W.; Qi, R.; Han, Y.; Wu, R.; Wang, Y.; Xu, H.*: Peptide-Induced DNA Condensation into Virus-Mimicking Nanostructures. ACS Applied Materials & Interfaces 2018, 10, 24349-24360.(SCI一区,IF:8.097)

27)Cao, M.*; Zhao, W.; Wang, L.; Li, R.; Gong, H.; Zhang, Y.; Xu, H.; Lu, J. R.*: Graphene Oxide-Assisted Accumulation and Layer-by-Layer Assembly of Antibacterial Peptide for Sustained Release Applications. ACS Applied Materials & Interfaces 2018, 10, 24937-24946.(SCI一区,IF:8.097)

28)Cao, M.; Lu, S.; Zhao, W.; Deng, L.; Wang, M.; Wang, J.; Zhou, P.; Wang, D.; Xu, H.*; Lu, J. R.*: Peptide Self-Assembled Nanostructures with Distinct Morphologies and Properties Fabricated by Molecular Design. ACS Applied Materials & Interfaces 2017, 9, 39174-39184.(SCI一区,IF:8.097)

29)Cao, M.*; Zhao, W.; Zhou, P.; Xie, Z.; Sun, Y.; Xu, H.*: Peptide nucleic acid-ionic self-complementary peptide conjugates: highly efficient DNA condensers with specific condensing mechanism. RSC Advances 2017, 7, 3796-3803.(SCI二区,IF:3.108)

2.发明专利

1)曹美文,沈阳,王瑜,姚明宇,王生杰,夏永清. 一种复合水凝胶在重金属离子去除中的应用(ZL201910328332.5)

2)曹美文,沈阳,丁榛,姚明宇,王生杰. 一种用于表面污染物去除的可剥离水凝胶(ZL202010630656.7)

3)曹美文,赵文婧,卢沙,王瑜,王生杰,夏永清. 基因和化学药物共转运载体及其使用方法(ZL201811307307.0)

4)曹美文,聂焱,马晟焱,石永康,李智超,党梦涛,王生杰,夏永清. MXene/硅烷表面复合硅烷膜在金属腐蚀防护中的应用(ZL201910931909.1)

5)曹美文,赵文婧,谢子龙,徐海. 一种自组装肽及其作为DNA凝聚试剂的应用(ZL201710223138.1)

6)曹美文,徐海,赵文婧,卢沙,谢子龙. 一种可作为基因载体的两亲性多肽分子(ZL201710117069.6)

7)曹美文,王瑜,沈阳,王生杰,夏永清,吕建仁. 一种海藻酸钠抗菌敷料的制备方法(ZL201810373751.6)(已转化)

8)曹美文,赵文婧,谢子龙,卢沙,徐海. 一种酶响应性自组装肽及其应用(ZL201710223136.2)

9)曹美文,赵文婧,卢沙,徐海. 具有双重靶向性和选择性的抗肿瘤多肽分子及其应用(ZL201710499462.6)

10)曹美文,徐海,王继乾,王宁宁,谢子龙,赵文婧. 一种自组装抗菌肽(ZL201610265536.5)

11)曹美文,徐海,汪蕾,王玉鸣,陈翠霞,吕建仁. 一种高载药量的长效缓释抗菌薄膜及其制备方法(ZL201510794371.6)(已转化)

12)曹美文,徐海,王玉鸣,王宁宁,汪蕾. 一种石墨烯分散剂及石墨烯分散液的制备方法(ZL201410532476.X)

13)曹美文,徐海,汪蕾,王继乾,王栋,吕建仁. 一种高强度多肽水凝胶的制备方法(ZL201510697529.8)

14)曹美文,王玉鸣,徐海,汪蕾. 一种增加井壁稳定性并降低滤失的方法(ZL201410502665.2)

 

六、获奖情况

1.2020年,新疆维吾尔自治区科技进步奖一等奖。

 

七、联系方式

邮箱:mwcao@upc.edu.cn